Table 2.
Genotype distribution and allele frequency of polymorphism in patients with chronic ITP and healthy controls
| ITP (%) | Control (%) | P value | OR | 95%CI | Statistical model | |||
|---|---|---|---|---|---|---|---|---|
| IFN-γ | Genotype | TT | 3 (2.4) | 2 (1) | 0.38 | 2.44 | 0.40–14.80 | Recessive |
| TA | 15 (11.9) | 44 (21.8) | ||||||
| AA | 108 (85.7) | 156 (77.2) | 0.06 | 1.77 | 0.97–3.22 | Dominant | ||
| Alleles | T | 21 (8.3) | 48 (11.9) | 0.15 | 0.67 | 0.39–1.16 | ||
| A | 231 (91.7) | 356 (88.1) | 1.48 | 0.87–2.54 | ||||
| FN-γR | Genotypes | GG | 0 (0) | 0 (0) | - | - | - | |
| GA | 11 (8.7) | 22 (10.9) | ||||||
| AA | 115 (91.3) | 180 (89.1) | 0.53 | 1.28 | 0.60–2.73 | Dominant | ||
| Alleles | G | 11 (4.4) | 22 (5.4) | 0.54 | 0.79 | 0.38–1.66 | ||
| A | 241 (95.6) | 382 (94.6) | 1.26 | 0.60–2.65 | ||||
| IL-4 | Genotypes | CC | 17 (13.5) | 17 (8.4) | 0.14 | 1.70 | 0.83–3.46 | Recessive |
| CT | 56 (44.4) | 88 (43.6) | ||||||
| TT | 53 (42.1) | 97 (48.0) | 0.29 | 0.79 | 0.50–1.23 | Dominant | ||
| Alleles | C | 90 (35.7) | 122 (30.2) | 0.14 | 1.28 | 0.92–1.79 | ||
| T | 162 (64.3) | 282 (69.8) | 0.78 | 0.56–1.09 | ||||
| IL-4Rα | Genotypes | 88 (69.8) | 161 (79.7) | 0.04 | 0.59 | 0.35–0.98 | Dominant | |
| QR | 37 (29.4) | 37 (18.3) | ||||||
| RR | 1 (0.8) | 4 (2.0) | 0.65 | 0.40 | 0.04–3.58 | Recessive | ||
| Alleles | Q | 213 (84.5) | 359 (88.9) | 0.11 | 0.69 | 0.43–1.09 | ||
| R | 39 (15.5) | 45 (11.1) | 1.46 | 0.92–2.32 | ||||
ITP: immune thrombocytopenia, OR: odds ratios, 95% CI: 95% confidence intervals, IFN: interferon, IL: interleukin, Recessive: Recessive model, Dominant: Dominant model