Table 3.
Hazard ratios for seroconversion to persistent islet autoimmunity at 3 and 6 years of age for analgesic variables of interest
| Analgesic Variable | Exposed subjects n (%) | 3 Year Analysis | 6 Year Analysis |
|---|---|---|---|
| 398 antibody + subjects | 511 antibody + subjects | ||
| HR (95% CI) p-value | HR (95% CI) p-value | ||
| Acetaminophen, any exposure | 7496 (87.8%) | 1.01 (0.97, 1.05) 0.603 | 1.01 (0.98, 1.05) 0.576 |
| Acetaminophen with fever + infection | 5179 (60.6%) | 1.05 (1.01, 1.09) 0.022 | 1.03 (0.99, 1.08) 0.189 |
| Exposed <90 days of life | 220 (2.6%) | 0.97 (0.59, 1.61) 0.914 | 1.00 (0.68, 1.46) 0.986 |
| Exposed <180 days of life | 1519 (17.8%) | 1.07 (0.87, 1.32) 0.542 | 1.06 (0.88, 1.27) 0.527 |
| Exposed <365 days of life | 3795 (44.4%) | 1.06 (1.00, 1.12) 0.011 | 1.05 (0.99, 1.11) 0.101 |
| Acetaminophen without fever or infection | 5941 (69.6%) | 1.02 (0.98, 1.06) 0.346 | 1.01 (0.96, 1.05) 0.769 |
| Exposed <90 days of life | 4016 (47.0%) | 1.00 (0.90, 1.11) 0.994 | 0.99 (0.85, 1.14) 0.837 |
| Exposed <180 days of life | 4597 (53.8%) | 0.98 (0.84, 1.14) 0.814 | 0.97 (0.84, 1.13) 0.729 |
| Exposed <365 days of life | 5310 (62.2%) | 1.03 (0.99, 1.06) 0.114 | 1.02 (0.99, 1.06) 0.228 |
| NSAID, any exposure | 3874 (45.4%) | 1.01 (0.97, 1.05) 0.753 | 1.01 (0.97, 1.04) 0.763 |
| NSAID with fever + infection | 2652 (31.0%) | 1.01 (0.97, 1.05) 0.673 | 1.01 (0.98, 1.05) 0.459 |
| Exposed <90 days of life | 22 (0.3%) | 1.01 (0.92, 1.10) 0.897 | 1.00 (0.92, 1.09) 0.960 |
| Exposed <180 days of life | 223 (2.6%) | 0.99 (0.88, 1.11) 0.822 | 1.00 (0.94, 1.07) 0.927 |
| Exposed <365 days of life | 1318 (15.4%) | 1.01 (0.97, 1.06) 0.530 | 1.02 (0.98, 1.05) 0.378 |
| NSAID without fever or infection | 1955 (22.9%) | 1.00 (0.96, 1.05) 0.856 | 1.01 (0.97, 1.05) 0.623 |
| Exposed <90 days of life | 222 (2.6%) | 1.00 (0.88, 1.12) 0.943 | 0.99 (0.88, 1.12) 0.874 |
| Exposed <180 days of life | 458 (5.4%) | 0.99 (0.88, 1.11) 0.815 | 1.00 (0.94, 1.07) 0.956 |
| Exposed <365 days of life | 1120 (13.1%) | 1.01 (0.96, 1.06) 0.824 | 1.01 (0.97, 1.05) 0.638 |
| Any analgesic, any exposure | 7744 (91%) | 1.02 (0.99, 1.05) 0.130 | 1.02 (0.99, 1.04) 0.267 |
| Any analgesic with fever + infection | 5699 (67%) | 1.06 (0.97, 1.15) 0.219 | 1.02 (0.94, 1.10) 0.667 |
Each hazard ratio is calculated from a Cox proportional hazards model with the analgesic variable and covariates indicated in text