Figure 1. Atorvastatin Activates sAPP_α Shedding Out of Proportion to Its Effect on holoAPP or csAPP.

(A) SweAPP N2a cells were treated with atorvastatin (Atv) for 24 h and then surface biotinylation was performed as described in Methods. Evaluation of csAPP was performed by immunoprecipitation–immunoblot after surface biotinylation, while holoAPP and sAPP_α were evaluated by immunoblot as described in Methods. C, control.

(B) Graphic representation of data. Y-axis shows effect of treatment (in arbitrary units) divided by effect of untreated control (in arbitrary units); n = 3 independent experiments; *, p < 0.05; **, p < 0.01; Student's t test).