Figure 3. Simultaneous Treatment of SweAPP N2a Cells with a Statin and FTI-1 Causes Greater sAPP_α Shedding Than Either Drug Alone.

(A) SweAPP N2a cells were treated for 24 h with atorvastatin (Atv, 5 μM), simvastatin (Sim, 1 μM), FTI-1 (5 μM), or a combination of FTI-1 plus a statin. Levels of sAPP_α (top panel) or holoAPP (bottom panel) were evaluated as described in Methods. C, control.

(B) Graphic representation of data. Y-axis shows effect of treatment (in arbitrary units) divided by effect of untreated control (in arbitrary units); n = 3 independent experiments; *, p < 0.05 versus control; **, p < 0.05 versus atorvastatin alone; ***, p < 0.05 versus simvastatin alone; Student's t test).