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. 2017 Feb 16;31(6):2352–2363. doi: 10.1096/fj.201601172R

Figure 3.

Figure 3.

HFD-fed offspring require a longer stimulus to perform correct responses. A) As shown in the schematic, on the 5-CSRTT titration training, response performed within each trial directly impacted the stimulus length of the subsequent trial. This allowed each animal to reach an individual set point for the task. B) HFD-fed offspring required the longest stimulus to perform a correct trial; however, this was ameliorated by MS. C) MS significantly decreased the median stimulus needed to perform a correct response. D) MS increased the number of trials performed during the 30-min session. E) MS decreased the time to complete a successful trial within this schedule. F) MS significantly increased the number of premature errors, but did not alter incorrect or omission errors. G) As designed, animals performed approximately 50% of trials successfully within this titration schedule. (n: SC = 11, HFD = 10, SC + MS = 13, HFD + MS = 16 in all figures.) $P < 0.05 main effect of MS; *P < 0.05 SC vs. HFD; ^P < 0.05 HFD vs. HFD + MS.