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Light–dark box test and FST reveal HCM-related mood disorder-like phenotype in aged female mice. A) Anxiety-like behavior in the light–dark box test. B) Number of transitions between the light and dark compartments. C) Depression-like behavior in the FST. Data are means ± sem; light–dark box test (n = 6–7/group, young adult; n = 12–14/group, aged adult; FST n = 8/group, young adult; n = 13–16/group, aged adult). *P < 0.05 vs. control.
