Figure 1.

Male and female mice aged 16 wk were treated with PBS (open symbol) or 3000 U/kg EPO (solid symbol) 3 times a week for 3 wk. A, B) Cumulative weight changes in male mice on RCD (A) and HFD (B). C, D) Cumulative weight changes in female mice on RCD (C) and HFD (D). E–G) Summary of changes in body weight (E), fat mass (F), and lean mass (G) before and after PBS or EPO treatment. H) Average food intake in mice treated with PBS or EPO (n = 6 in each group). *P < 0.05; **P < 0.01; ^#P < 0.001.