Figure 7.

Chronic cholestatic injury with bile duct loss due to lenolidomide. The portal areas have mild inflammation and lack either a bile duct or ductular reaction (A). The absence of duct structures is confirmed by keratin 7 staining, which also demonstrates the aberrant expression of keratin 7 in periportal hepatocytes that occurs in chronic cholestasis (B). As with the other cholestatic patterns, there is often cholestasis in zone 3 (C)