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Microvesicular steatosis in DILI. In fialuridine injury there is diffuse microvesicular steatosis because the drug interferes with mitochondrial DNA replication in all of the hepatocytes. The cells have a uniform, foamy appearance (A). Microvesicular steatois can also be seen as a focal injury in other forms of DILI. In (B) this small cluster of foamy cells is seen in a case of isoniazid injury.
