Table 1. Proinflammatory cytokine suppression in distant organs after intestinal I/R.
The systemic inflammatory response variables TNF-α, IL-6 and IL-1β in the sham, DMSO (vehicle) and Alda-1 groups were assessed using ELISA in mice that underwent 60 min of ischaemia followed by 120 min of reperfusion. Data are denoted as means±S.D.s (n=5–6/group).
| Ischaemia–reperfusion | ||||
|---|---|---|---|---|
| Organ | Cytokine (pg/mg) | Sham | DMSO (vehicle) | Alda-1 |
| Brain | TNF-α | 21.03±7.37 | 64.29±16.72* | 49.43±6.18*# |
| IL-6 | 5.00±2.85 | 11.64±2.63* | 6.79±2.82# | |
| IL-1β | 2.33±0.63 | 7.19±0.68* | 5.83±1.04*# | |
| Heart | TNF-α | 36.69±22.52 | 94.52±40.19* | 42.57±13.82# |
| IL-6 | 14.13±7.60 | 26.03±14.29 | 21.19±9.38 | |
| IL-1β | 3.69±1.83 | 6.21±1.19* | 4.15±1.82 | |
| Kidney | TNF-α | 108.66±7.38 | 153.18±6.83* | 114.79±6.74# |
| IL-6 | 47.06±6.00 | 65.21±12.19* | 33.29±7.64*# | |
| IL-1β | 20.54±9.17 | 64.15±9.86* | 58.48±10.32* | |
#P<0.05 vs DMSO and *P<0.05 vs sham using one-way ANOVA and LSD tests.