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SPR analysis of the Aβ association rate as function of monomer concentration at pH 7.4 and 5.5. The monomeric Aβ variants at the indicated concentrations were probed towards their corresponding immobilised fibrils. The rates were acquired by measuring the end state of association after exactly 1 min of injection. pH 7.4 (filled squares), pH 5.5 (open squares). (A) Aβ1–40 wt. (B) Aβ1–40 H6A. (C) Aβ1–40 H13A. (D) Aβ1–40 H14A. (E) Aβ1–40 H6A, H13A, H14A.
