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Schematic of the PBPK model for ETBE and its metabolite TBA in rats was adapted from Leavens and Borghoff (2009). Model equations, along with the schematic for the description of ETBE and TBA binding to α2u–globulin in the male rat kidney is described in Leavens and Borghoff (2009). Biochemical and physiological parameters and respective values are presented in Table 3. ETBE, ethyl tertiary‐butyl ether; TBA, tertiary‐butyl alcohol.
