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. 2016 Nov 24;37(5):621–640. doi: 10.1002/jat.3412

Figure 8.

Figure 8

Percentage of dose exhaled or excreted in urine, (A) following a single oral dose (5 or 4000 mg kg−1) of 14C–ETBE to male rats (JPEC, 2008b). (B) Percentage of dose excreted in urine following a 4 h inhalation exposure to 4 or 40 ppm ETBE (Amberg et al., 2000). (C) Single 6 h NO exposure of male (C) or female (D) rats to 500, 1750 or 5000 ppm 14C–ETBE (Borghoff & Asgharian, 1996). Bars represent actual data collected (mean ± SD) from studies reported (Table 2 and Supporting information) or model simulation based on model parameter values provided in Table 3. ETBE, ethyl tertiary‐butyl ether; NO, nose‐only.