Figure 10.

TBA kidney/blood ratio in male (A, single 6 h exposure; C, repeated exposure 6 h day⁻¹ for 8 days) and female (B, single 6 h exposure; D, repeated exposure 6 h day⁻¹ for 8 days) F344 rats at various time points following inhalation exposure to TBA at nominal concentrations of 250, 450 or 1750 ppm. Each bar represents the mean kidney/blood ratio calculated from the study data (Leavens & Borghoff, 2009; see Table 2 and Supporting information) with model simulations of these ratios based on model parameter values provided in Table 3. As described by Leavens and Borghoff (2009), TBA binding to α2u–globulin is described in the male, but not female rat kidney. TBA, tertiary‐butyl alcohol.