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. 2017 May 17;37(3):BSR20170105. doi: 10.1042/BSR20170105

Figure 4. Decreased GLT25D1 coincides with loss of HMW adiponectin.

Figure 4

Mice were fed a standard chow or HFD for 5 weeks (n=4). HMW adiponectin and GLT25D1 were analysed for changes in GLT25D1 with high-fat feeding. (A) At 5 weeks, the mass of the animal was unchanged. (B) At 5 weeks, epididymal fat mass was significantly increased (t-test, *P=0.003, P<0.05). (C) There was no significant difference in the total amount of adiponectin in the serum. (D) There was a significant decrease in the amount of HMW adiponectin in the serum (t-test,*P=0.0247, P<0.05). (E) There was a significant decrease in the amount of adiponectin relative to fat mass (t-test, *P=0.0140, P<0.05). Therefore, there was a significant decrease in the secretion of total adiponectin. (F) There was a significant decrease in the amount of HMW adiponectin relative to fat mass (t-test,* P=0.020, P<0.05). Therefore, there was a significant decrease in the secretion of HMW adiponectin. (G) GLT25D1 was analysed in mouse epididymal tissue. There was a significant decrease in GLT25D1 after 5 weeks HFD relative to standard chow control mice (t-test, *P =0.0117, P<0.05, n=4).