Figure 2.

Selective incorporation of the 3‐S‐oxetane motif into proteins. a) General strategy with 1. b) Protein scope with C2Am and AnxV. c) MS² spectrum of the m/z 511.25 doubly charged ion of the tryptic peptide VPYCELGGK, containing the 3‐S‐oxetane modification at the original Cys95 residue in 2; the fragment ions generated are consistent with the mass of the modification. d) Biacore SPR analysis of C2Am and 2 against PS; the data represent mean±SD obtained from two independent experiments performed in duplicate.