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Selective incorporation of an S‐to‐S/N oxetane linker on proteins. a) General strategy with 4. b) Protein scope with C2Am and AnxV. c) Nucleophile scope with 5. d) Analysis of the flexibility of S‐to‐S/N oxetane linker in 7 a (lower panel) vs. a standard 3C‐linear linker in 8 (upper panel) obtained from 100 ns MD simulations. The data presented in this Figure corresponds to the average structure of both linkers through the simulations.
