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. 2017 Mar 30;61(5):1600372. doi: 10.1002/mnfr.201600372

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© 2017 The Authors. Molecular Nutrition & Food Research published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(a) Dietary nitrate had no effect on (a) mineral apposition rate (MAR), (b) mineralizing perimeter (mineralizing bone/bone perimeter, M.Pm/B.Pm), (c) bone formation rate (bone formation rate /bone perimeter, BFR/B.Pm), or (d) osteoclast perimeter (osteoclast perimeter /bone perimeter, Oc.Pm/B.Pm) in the proximal tibia metaphysis of ovariectomized Sprague Dawley rats as determined by histology; Dietary nitrate had no effect on serum biochemical markers of (e) bone formation (Osteocalcin), or f) bone resorption (CTx). OVX, ovariectomized; LDN, low‐dose nitrate 0.1 mmol sodium nitrate kg/ day; and HDN, high‐dose nitrate 1 mmol sodium nitrate kg/ day. Data represent means ±SE (n = 10 rats/group). ^*Differences were considered significant at Benjamini–Hochberg adjusted p < 0.05; Groups not sharing a superscript are significantly different.