Figure 1.

Association between the antineutrophil cytoplasmic autoantibody–associated vasculitis variant rs62132293 and increased expression of PRTN3. Levels of mRNA for PRTN3 were measured using quantititative polymerase chain reaction amplification of cDNA from peripheral blood polymorphonuclear leukocytes obtained from healthy donors with the rs62132293 CC genotype (n = 7), rs62132293 CG genotype (n = 9), or rs62132293 GG genotype (n = 6). PRTN3 expression levels, relative to the values for the calibrator reference gene COX5B, are presented as box plots, in which the boxes represent the 25th to 75th percentiles, the horizontal line within the boxes indicates the median, and the bars outside the boxes indicate the lowest and highest values. Data are representative of 3 independent experiments. P values were determined by unpaired t‐test.