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. 2017 May 16;10(5):e004508. doi: 10.1161/CIRCEP.116.004508

Figure 2.

Figure 2.

The effect of ivabradine on automaticity of induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs). A, Representative experiment showing action potentials recorded in absence (control panel) and presence of 0.1, 1, 3, and 10 μmol/L ivabradine. B, Summary of mean beat rate in absence and presence of 0.1, 1, 3, and 10 µmol/L ivabradine. Ivabradine induced a dose-dependent decrease in the mean beat rate (n=12 cells). In B, One-way ANOVA was performed followed by the Holm–Sidak method. *P<0.05 vs control. P <0.05 per Holm–Sidak method was considered statistically significant. All experiments were performed at 36°C.