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. 2017 May 16;10(5):e004508. doi: 10.1161/CIRCEP.116.004508

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© 2017 The Authors.

Circulation: Arrhythmia and Electrophysiology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — The effect of ivabradine on I_f in induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs). Combined current- and voltage-clamp recordings were performed in the same cell. A, Spontaneous action potentials recorded in control Tyrode solution (left). Ivabradine at 10 μmol/L blocked automaticity (right). B, A representative experiment illustrating the dose-dependent attenuation of I_f by ivabradine. C, In the voltage-clamp protocol, the membrane was clamped from a holding potential of −40 to −120 mV in 10 mV steps for 2 s pulse duration. Interpulse interval: 15 s. D, Current-voltage relations of I_f (n=7 cells) illustrating the dose-dependent I_f attenuation by ivabradine. BaCl₂ (500 μmol/L) was included in the extracellular solution to inhibit I_K1. All experiments were performed at 36°C.