Table 2.
Safety parameters at Day 1
| Systolic BP (mmHg) | Diastolic BP (mmHg) | Heart Rate (beats/min) | Respiratory Rate (breaths/min) | O2 Saturation (%) | Temperature (°C) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls | PH | Controls | PH | Controls | PH | Controls | PH | Controls | PH | Controls | PH | |
| Baseline | ||||||||||||
| ∼ −10 min | 116 ± 11 | 116 ± 15 | 70 ± 9 | 72 ± 8 | 59 ± 7 | 69 ± 13 | 15 ± 3 | 17 ± 2 | 99 ± 0.9 | 95 ± 2.7 | 36.6 ± 0.2 | 36.5 ± 0.3 |
| 5 min | 113 ± 11 | 113 ± 14 | 69 ± 6 | 71 ± 8 | 58 ± 7 | 68 ± 11 | 14 ± 3 | 18 ± 2 | 99 ± 1.1 | 94 ± 3.1 | 36.6 ± 0.1 | 36.7 ± 0.1 |
| 10 min | 110 ± 10 | 110 ± 14 | 67 ± 6 | 68 ± 9 | 59 ± 8 | 68 ± 12 | 14 ± 2 | 18 ± 2 | 98 ± 1.4 | 93 ± 3.5 | 36.6 ± 0.2 | 36.7 ± 0.1 |
| 15 min | 109 ± 9 | 109 ± 14 | 65 ± 7 | 67 ± 9 | 59 ± 7 | 69 ± 12 | 13 ± 2 | 18 ± 2 | 99 ± 1.3 | 93 ± 3.6 | 36.6 ± 0.1 | 36.7 ± 0.2 |
| 30 min | 111 ± 11 | 109 ± 13 | 66 ± 7 | 66 ± 10 | 61 ± 7 | 70 ± 12 | 14 ± 3 | 18 ± 2 | 99 ± 1.4 | 93 ± 3.8 | 36.6 ± 0.1 | 36.6 ± 0.3 |
| 60 min | 113 ± 9 | 114 ± 14 | 68 ± 8 | 69 ± 8 | 61 ± 9 | 70 ± 12 | 15 ± 2 | 18 ± 2 | 99 ± 0.7 | 95 ± 3.5 | 36.6 ± 0.1 | 36.6 ± 0.3 |
| Maximum change | −8.7 (−12.0, −5.3) |
−11.2 (−14.3, −8.0) |
−6.7 (−8.8 -4.5) |
−8.6 (−10.8, −6.3) |
4.9 (2.5, 7.4) |
3.7 (1.7, 5.8) |
0.13 (−0.78, 1.04) |
0.20 (−0.40, 0.80) |
−1.3 (−2.0, −0.5) |
−2.9 (−3.6, −2.1) |
0.11 (0.03, 0.20) |
0.08 ( −0.01, 0.18) |
Values are mean ± sd or mean (95% CI)