Table 4.

Inhibition of MTAP/MTAN with Transition State Analogue Inhibitors^a

	MT-ImmA $K_{\mathrm{i}}^{\ast }$		MT-DADMe-ImmA $K_{\mathrm{i}}^{\ast }$		pCl-PhT-DADMe-ImmA $K_{\mathrm{i}}^{\ast }$
enzyme	measured	literature	measured	literature	measured	literature
hsMTAP	330 ± 68 pM	1 ± 0.5 nM	63 ± 10 pM	90 ± 10 pM	47 ± 13 pM	10 ± 5 pM
hpMTAN	66 ± 11 pM	40 ± 20 pM	15 ± 1.4 pM	89 ± 19 pM	360 ± 32 pM	570 ± 90 pM

^aThe $K_{\mathrm{i}}^{\ast }$ values of three transition state analogues were measured (Figures 3 and 4) and compared to literature values. Most values are similar to previously reported values, but show a smaller margin of error.^21,22