Fig. 2.

Median [interquartile range (IQR)] daily budesonide/formoterol actuations in the 14 days prior to, and the 14 days following a severe exacerbation in the SMART group. Day 0 represents the initiation of corticosteroid therapy. There were 35 severe exacerbations in the SMART group. For patients with repeat exacerbations, a minimal interval of 28 days between exacerbations was required, to avoid overlap of data within the same participant. One patient in the SMART group had a second severe exacerbation within 28 days following the prior exacerbation. Thus, electronic data for 34 severe exacerbations were included in the plots of medication use patterns for the SMART group