Fig. 3.
Change in Potts energy correlates with change in experimental fitness. (A) Changes in melting temperature (Tm) for individual sequences relative to a reference sequence extracted from literature (Muzammil et al. 2003; Chang and Torbett 2011; Louis et al. 2011). These sequences differ from the wildtype by 1–2 mutations (Chang and Torbett 2011) up to 10–14 mutations (Muzammil et al. 2003; Louis et al. 2011). (B) Change in relative infectivty as measured by replicative capacity assay for individual sequences containing only single point mutations (Henderson et al. 2012) and 1–5 mutations (van Maarseveen et al. 2006). In both panels a linear regression fit with Pearson’s R and associated two-tailed P value are provided in the legend.