Fig 6. Frequency dependent increase in contractile response of isolated detrusor strips in response to EFS trains of 20 pulses at frequencies ranging from 0.25 to 40 Hz.
Representative traces showing contractile responses of detrusor strips from drug-naïve (a) and MPTP-treated common marmoset (b) in response to trains of 20 pulses at frequencies ranging from 0.25 to 40 Hz. EFS-evoked contractile responses of MPTP-treated detrusor was larger at all stimulation frequencies above 1.0 Hz (c). Time course of EFS-evoked contractile responses of detrusor strips from normal and MPTP-treated common marmosets at 4 Hz (d) and 40 Hz (e) shows a biphasic contractile profile with two distinct 1st and 2nd peaks. The vertical lines marked 1st and 2nd indicate peak phasic and tonic responses respectively. Each data point represents mean ± sem (n = 19–22) * P<0.05, **P<0.005.