Table 1. Characteristics of included studies.
| Study | Participants | NIHSS | Stroke | Time hours | Reference Standard | CT scanner | Coverage mm | Thickness mm | Color maps | Design |
|---|---|---|---|---|---|---|---|---|---|---|
| Campbell 2012[11] | 364 | 10(5–18) | 277(76%) | 9(3.1) | Follow up CT/MRI | Siemens 16 slice | 24 | 12 | TTP, CBV, CBF | Retrospective |
| Chen 2012[12] | 20 | NS | 20(100%) | 20(NS) | Follow up MRI | Toshiba 320 slice | 160 | 0.5 | CBV, CBF,MTT, TTP | Prospective |
| Dai 2009[13] | 23 | NS | 23(100%) | NS | Follow up MRI | Siemens 64 slice | 28.8 | 7.2 | CBV, CBF, TTP | Retrospective |
| Eastwood 2003[14] | 15 | 12.6 | 14(93%) | 8(3.1) | Follow up MRI | GE 1 slice | 5–10 | 5–10 | CBV, CBF, MTT | Prospective |
| Eckert 2010[15] | 107 | 8.3 | 76(71%) | 6(NS) | Follow up CT/MRI | Philips 40 slice | 40 | 10 | CBV, MTT | Prospective |
| Eseban 2004[16] | 42 | NS | 29(69%) | 6(NS) | Follow up CT/MRI | GE 16 slice | 20 | 5–10 | CBV, CBF, MTT | Retrospective |
| Hana 2014[17] | 87 | NS | 87(100%) | NS | Follow up MRI | GE 64 slice | NS | NS | CBV, CBF, MTT | Retrospective |
| Kloska2004[18] | 41 | 10.5 | 38(93%) | 8(3.1) | Follow up CT/MRI | Siemens 4 slice | 20 | 10 | TTP, CBV, CBF | Prospective |
| Koenig 1998[19] | 32 | NS | 28(88%) | 6(2.7) | Follow up CT/MRI | Siemens slip-ring | 10 | 10 | CBF | Prospective |
| Langer 2007[20] | 50 | 6(0–28) | 38(76%) | 8(NS) | Follow up CT | GE multi slice | NS | NS | CBV, CBF, MTT | Prospective |
| Leng 2003[21] | 46 | NS | 34(74%) | 6(NS) | Follow up CT | Maconi multi slice | NS | 20 | CBF, TTP, MTT | NS |
| Lin 2009[22] | 100 | 12(4–8)* | 65(65%) | 3(NS) | Follow up MRI | Siemens16 slice | 24 | 12 | TTP, CBV, CBF | Retrospective |
| Liu 2005[23] | 31 | NS | 31(100%) | 24(NS) | Follow up CT/MRI | 8 slice | NS | NS | CBV, CBF, MTT | NS |
| Pepper 2006[24] | 15 | 15(11–20) | 14(93%) | 6(4.1) | Follow up CT/MRI | Philips 16-slice | 24 | 6 | CBV, CBF,MTT | Prospective |
| Rai2008[25] | 422 | NS | 157(37%) | 15(3.9) | Follow up MRI | GE multi slice | 20 | 10 | CBV, CBF, MTT | Retrospective |
| Reichenbach 1999[26] | 20 | NS | 20(100%) | 6(2.8) | Follow up CT/MRI | Siemens slip-ring | 10 | 10 | TTP | Prospective |
| Roberts 2001[27] | 12 | NS | 9(75%) | 6(NS) | Follow up CT/MRI | GE multi slice | 40 | 10 | TTP, CBV, CBF, MTT | NS |
| Rother2000[28] | 22 | 13.2 | 20(91%) | 6(2.4) | Follow up CT | Siemens slip-ring | 10 | 10 | TTP | Prospective |
| Schramm 2004[29] | 22 | 10(4–8) | 13(59%) | 6(2.3) | Follow up CT | Siemens multi slice | 20 | 10 | TTP, CBV, CBF | Prospective |
| Sillanpaa 2011[30] | 72 | 7(4–2) | 72(100%) | 3(NS) | Follow up CT | GE 16 slice, Philips 64 slice | 80 or 20 | 10 or 5 | CBV, CBF, MTT | Retrospective |
| Suzuki 2005[31] | 118 | NS | 110(93%) | 10(NS) | Follow up CT/MRI | GE 64 slice | 30 | 10 | CBV, CBF, MTT | NS |
| Wintermark 2005[32] | 46 | NS | 26(57%) | 12(5.5) | Follow up CT/MRI | Philips multi slice | 40 | 10 | TTP, CBV, CBF, MTT | Retrospective |
| Youn2008[33] | 58 | NS | 51(88%) | 24(3.4) | Follow up MRI | Philips 64 slice | 80 | 10 | TTP, CBV, CBF, MTT | Retrospective |
| Zebedin2011[34] | 10 | NS | 2(20%) | 9(NS) | Follow up CT | Toshiba 320-MDCT | 5 | 5 | CBV, CBF, MTT | Retrospective |
| Zhu2011[35] | 38 | NS | 38(100%) | 6(NS) | DWI | Philips 64 slice | 40 | 5 | CBV, TTP | NS |
| Sporns2016 [36] | 267 | 4 (4.6–5.3) * | 188(70%) | 0–9 | Follow up MRI | 128-slice Siemens dual-source CT | 99 | 5 | CBV, CBF,MTT, TTD | Retrospective |
| van der Hoeven2015[37] | 88 | 2.5 (2–5)* | 76(86%) | 3.8(2.6) | Follow up CT/MRI | 40–320 detector C T(Philips,Siemens, GE, Toshiba) | >40 | 5 | CBF, CBV, MTT | Prospective |
* median (IQR)