Table 1. Demographic, sleep, and laboratory data of study participants in the microarray gene expression experiment (study cohort 1 and 2).
| Study Cohort 1 | Study Cohort 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Subjects with primary snoring (PS) N = 6 | Moderate-severe OSA patients (MSO) N = 15 |
Very severe OSA patients(VSO) N = 12 | Very severe OSA patients on CPAP (VSOC) N = 15 |
P value | Subjects with primary snoring(PS) N = 16 |
Moderate-severe OSA patients (MSO) N = 18 |
Very severe OSA patients (VSO) N = 18 |
Very severe OSA patients on CPAP (VSOC) N = 16 |
P value | |
| Age, years | 51.0±11.3 | 46.9±11.9 | 47±11.4 | 50.4±8 | 0.592 | 49.7±9.3 | 47.6±11.5 | 47.5±10.2 | 50.4±8.0 | 0.766 |
| Male Sex, n(%) | 4 (66.7) | 12 (80) | 9 (81.8) | 12 (75) | 0.871 | 8 (50) | 14 (77.8) | 16 (88.9) | 12 (75) | 0.075 |
| BMI, kg/m2 | 25.1±2 | 27.2±3.8 | 28±3.6 | 28.4±4.5 | 0.231 | 26.6±3.4 | 27.2±3.8 | 26.9±4.5 | 28.3±4.5 | 0.647 |
| AHI,events/hour | 4.2±2.1 | 34.1±8.8 | 67.4±12.3 | 66.2±24.3 | <0.001 | 3.1±2.5 | 34.8±9.5 | 70.3±12.1 | 64.5±24.5 | <0.001 |
| ODI,events/hour | 2.4±1.4 | 24.9±13.8 | 62.1±11.9 | 58.1±26.4 | <0.001 | 2.1±2.0 | 23.9±13.2 | 59.1±22.1 | 58.1±26.4 | <0.001 |
| Mean SaO2, % | 96.8±0.4 | 95.2±1.9 | 93.3±2.2 | 93.2±3.6 | <0.001 | 97.2±0.7 | 95.3±1.8 | 93.6±2.3 | 93.2±3.6 | <0.001 |
| Minimum SaO2, % | 88.5±1.8 | 78.3±8.5 | 65.5±12.7 | 72±11.3 | <0.001 | 89.3±3.4 | 78.9±8.2 | 67.6±12.9 | 72.0±11.3 | <0.001 |
| Arousal index | 10.9±9.6 | 30.5±24.4 | 46.6±29.5 | 63.6±41.9 | 0.002 | 13.9±10.5 | 32.9±25.1 | 46.9±27.3 | 63.6±41.9 | <0.001 |
| ESS | 12.3±5.9 | 8.7±5.4 | 10.5±4.7 | 14.1±4.7 | 0.026 | 6.8±6.2 | 8.4±5.4 | 11.1±5.1 | 14.1±5.7 | 0.003 |
| Smoking, n(%) | 5 (83.3) | 9 (60) | 6 (54.5) | 11 (68.8) | 0.612 | 2 (14.3) | 7 (38.9) | 7 (38.9) | 5 (31.3) | 0.421 |
| Alcoholism, n(%) | 5 (83.3) | 7 (46.7) | 8 (72.7) | 11 (68.8) | 0.322 | 0 (0) | 2 (11.1) | 2 (11.1) | 0 (0) | 0.315 |
| Cholesterol, mg/dl | 190.2±36.2 | 203.1±47.3 | 174.6±59.3 | 164.4±71.5 | 0.356 | 190.2±39.6 | 187.6±66.4 | 184.6±53.8 | 164.5±71.5 | 0.621 |
| Triglycerides, mg/dl | 130.8±67 | 199±126.4 | 155.5±59.9 | 194.6±151.9 | 0.499 | 120.6±56.8 | 194.8±121.1 | 155.4±60.1 | 194.6±151.9 | 0.153 |
| HDL, mg/dl | 59.8±14.5 | 52.7±10.9 | 49.9±4.7 | 48.8±18.4 | 0.193 | 57.5±11.2 | 49.1±16.1 | 52.7±9.5 | 48.7±13.4 | 0.321 |
| LDL, mg/dl | 106.7±33.6 | 110.1±31.6 | 102.5±31.7 | 100.4±40.1 | 0.956 | 102.2±31.4 | 110.7±33.1 | 107.2±38.1 | 100.4±40.1 | 0.866 |
| Glucose, mg/dl | 96.3±5.8 | 101.3±15.7 | 101.6±12.3 | 107.9±25.5 | 0.355 | 94.8±5.7 | 99.7±15.7 | 97.2±13.7 | 107.9±25.4 | 0.194 |
| Co-morbidity,n(%) | ||||||||||
| Hypertension | 2 (33.3) | 6 (40) | 2 (18.2) | 8 (50) | 0.271 | 4 (25) | 7 (38.9) | 6 (33.3) | 8 (50) | 0.516 |
| Diabetes mellitus | 0 (0) | 0 (0) | 0 (0) | 3 (18.8) | 0.071 | 0 (0) | 0 (0) | 0 (0) | 3 (18.8) | 0.017 |
| Cardiac disease | 1 (16.7) | 1 (6.7) | 1 (9.1) | 2 (12.5) | 0.752 | 2 (12.5) | 2 (11.1) | 2 (11.1) | 2 (12.5) | 0.999 |
| Stroke | 1 (16.7) | 0 (0) | 0 (0) | 0 (0) | 0.067 | 1 (6.3) | 0 (0) | 0 (0) | 0 (0) | 0.348 |
| Chronic kidney disease | 1 (16.7) | 1 (6.7) | 1 (8.3) | 2 (13.3) | 0.384 | 1 (6.3) | 1 (5.6) | 2 (11.1) | 2 (12.5) | 0.86 |
BMI = body mass index; AHI = apnea hypopnea index; ODI = oxygen desaturation index; HDL = high density lipoprotein; LDL = low density lipoprotein