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. 2017 May 17;12(5):e0177435. doi: 10.1371/journal.pone.0177435

Table 2. Total antibiotic consumption by ATC code and age group (daily defined dose/1,000 inhabitants/day).

ATC 4-level (chemical subgroup level) 2007 2008 2009 2010 2011 2012 2013 2014
Penicillins with extended spectrum (J01CA)
    ≤ 6 years old 7.15 6.85 7.15 8.40 8.78 10.05 10.61 10.79
    07–19 years old 2.69 2.38 2.46 2.42 2.23 2.29 2.30 2.48
    20–64 years old 3.58 3.25 3.04 3.01 2.94 2.92 2.83 2.82
    ≥ 65 years old 5.05 4.70 4.42 4.39 4.28 4.33 4.31 4.32
    Total 3.82 3.49 3.36 3.41 3.35 3.45 3.43 3.47
Combinations of penicillins (J01CR)
    ≤ 6 years old 21.84 23.91 24.23 27.45 26.35 28.28 28.42 27.79
    07–19 years old 5.74 6.50 7.55 7.48 6.64 6.68 6.82 7.55
    20–64 years old 3.54 4.27 4.46 4.55 4.37 4.47 4.50 4.88
    ≥ 65 years old 4.15 5.01 5.17 5.23 5.03 5.28 5.32 5.68
    Total 5.28 6.06 6.36 6.60 6.23 6.44 6.49 6.83
First & second-generation cephalosporins (J01DC)
    ≤ 6 years old 7.12 7.63 7.91 8.12 6.67 6.52 6.03 5.56
    07–19 years old 4.33 4.82 5.77 6.05 5.42 5.63 5.67 6.02
    20–64 years old 5.11 5.46 5.74 5.97 5.81 6.04 6.14 6.40
    ≥ 65 years old 8.08 8.64 8.84 8.99 8.63 9.04 9.12 9.36
    Total 5.41 5.82 6.22 6.46 6.12 6.36 6.43 6.66
Third & fourth-generation cephalosporins (J01DD)
    ≤ 6 years old 2.67 3.06 3.49 4.50 4.62 5.26 5.26 5.33
    07–19 years old 0.56 0.70 0.90 0.94 0.98 1.03 1.08 1.24
    20–64 years old 0.84 0.90 0.95 0.99 1.02 1.08 1.07 1.12
    ≥ 65 years old 2.69 2.89 3.00 3.13 3.20 3.42 3.32 3.40
    Total 1.10 1.22 1.33 1.45 1.50 1.61 1.62 1.69
Macrolides (J01FA)
    ≤ 6 years old 7.73 7.97 8.79 10.54 11.99 10.38 9.13 9.51
    07–19 years old 2.23 2.58 3.39 3.78 4.03 3.76 3.71 4.44
    20–64 years old 1.99 2.27 2.60 2.80 2.86 3.03 3.12 3.45
    ≥ 65 years old 3.52 3.92 4.11 4.30 4.17 4.47 4.38 4.72
    Total 2.59 2.88 3.30 3.63 3.79 3.79 3.75 4.14
Fluoroquinolones (J01MA)
    ≤ 6 years old 0.06 0.05 0.04 0.00 0.00 0.00 0.00 0.01
    07–19 years old 0.68 0.66 0.66 0.21 0.19 0.20 0.17 0.13
    20–64 years old 2.89 2.91 2.86 2.80 2.75 2.82 2.67 2.50
    ≥ 65 years old 6.09 6.42 6.41 6.37 6.31 6.66 6.46 6.20
    Total 2.62 2.69 2.68 2.58 2.56 2.68 2.59 2.47
Others
    ≤ 6 years old 0.44 0.39 0.35 0.36 0.31 0.28 0.24 0.22
    07–19 years old 1.28 1.24 1.26 1.28 1.28 1.30 1.28 1.29
    20–64 years old 3.01 2.94 2.81 2.80 2.73 2.71 2.61 2.63
    ≥ 65 years old 4.36 4.32 4.13 4.08 3.83 3.90 3.70 3.66
    Total 2.66 2.62 2.52 2.53 2.46 2.47 2.39 2.41

Note: The number of inhabitants were based on the number of each age group

DID, DDD/1,000 inhabitants/day where DDD represents WHO defined daily doses