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BM from <2-month-old rabbits is characterized by the presence of osteoblasts (support B lymphopoiesis) and B lineage progenitors. By 2–4 months-of-age the BM microenvironment transforms, and no longer supports B lineage development. The BM of >2-month-old rabbits fills with adipocytes and myeloid cells, which produce inflammatory mediators that specialize the BM for myelopoiesis.
