Table 1.
A | |||||||
---|---|---|---|---|---|---|---|
Relative CBV responses to SD |
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Group | Dose | Phase | # of measurements | Hyperemia | Oligemia | Time of hyperemia | Time of oligemia |
First group, n = 5 | 2 mg/kg/h | Before | 80 | 21.3 ± 1.1% | − 10.2 ± 2.8% | 3.02 min ± 23 s | 11.03 min ± 66 s |
During | 46 | 14.0 ± 1.3% | − 13.9 ± 3.4% | 2.34 min ± 25 s | 8.26 min ± 77 s | ||
After | 64 | 13.7 ± 1.2% | − 10.6 ± 3.0% | 2.21 min ± 24 s | 9.16 min ± 69 s | ||
Second group, n = 5 | 4 mg/kg/h | Before | 80 | 18.6 ± 1.1% | − 17.9 ± 2.8% | 4.00 min ± 23 s | 11.06 min ± 66 s |
During | – | – | – | – | – | ||
After | 62 | 12.3 ± 1.2% | − 18.5 ± 3.0% | 3.35 min ± 24 s | 8.44 min ± 70 s | ||
B | |||||||
Relative arterial diameter responses to SD |
|||||||
Group |
Dose |
Phase |
# of measurements |
Vasodilation |
Vasoconstriction |
Post-SD |
Time of dilation |
First group, n = 5 | 2 mg/kg/h | Before | 40 | 39.5 ± 4.9% | − 14.3 ± 2.8% | 4.1 ± 2.2% | 1.90 min ± 8 s |
During | 23 | 20.4 ± 5.5% | − 13.9 ± 3.3% | 5.5 ± 2.9% | 1.21 min ± 10 s | ||
After | 32 | 15.3 ± 5.1% | − 11.4 ± 2.9% | 5.7 ± 2.4% | 1.36 min ± 9 s | ||
Second group, n = 5 | 4 mg/kg/h | Before | 40 | 45.0 ± 4.9% | − 13.3 ± 2.8% | 6.6 ± 2.2% | 2.23 min ± 8 s |
During | – | – | – | – | – | ||
After | 31 | 24.1 ± 5.1% | − 13.2 ± 3.0% | 1.7 ± 2.5% | 1.33 min ± 9 s | ||
C | |||||||
Relative CBF and CBV responses to SD |
|||||||
Group |
Dose |
Method |
Phase |
# of SDs |
Hyperemia |
Time of hyperemia |
|
Second group, n = 4 | 4 mg/kg/h | LDF | Before | 16 | 120.4 ± 59.6% | 5.83 min ± 90 s | |
During | – | – | – | ||||
After | 16 | 104.4 ± 50.7% | 3.40 min ± 90 s | ||||
IOS | Before | 16 | 12.8 ± 4.1% | 3.34 min ± 60 s | |||
During | – | – | – | ||||
After | 16 | 9.0 ± 2.3% | 2.55 min ± 60 s |
Values are expressed as mean and standard deviation.
CBF: cerebral blood flow; CBV: cerebral blood volume; IOS: intrinsic optical signal imaging; LDF: laser-Doppler flowmetry; SD: spreading depolarization.