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. 2017 May 17;12(5):e0177786. doi: 10.1371/journal.pone.0177786

Fig 2. Thrombolysis of human and porcine clots.

Fig 2

(a) Fractional clot loss (FCL) for porcine clots in porcine plasma (n = 5, black), human clots in porcine plasma (n = 12, light grey), and porcine clots in human plasma (n = 12, dark grey) exposed to plasma alone, rt-PA (3.15 μg/mL), and rt-PA (3.15 μg/mL) with Definity® and intermittent 120 kHz ultrasound (US). Statistically significant differences in FCL (p<0.05) across treatments are denoted by (*). No difference (p>0.05) in FCL was observed for porcine clots in porcine plasma exposed to rt-PA without or with the use of Definity® and US as an adjuvant compared to plasma alone. (b) Average lytic rate (ALR) for the same clots and treatments shown in 2(a). Statistically significant differences in ALR (p < 0.05) across treatments are denoted by (*). † Data with human clots in human plasma (n = 12, white) was reproduced from [22].