Table 2. The distribution of SUD and age at diagnosis in case and control families.
| TOTAL N(%) |
ALC N(%) |
MULT N(%) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| SUD not present | SUD present | SUD not present | SUD present | SUD not present | SUD present | ||||
| Case families | |||||||||
| Probands | 0 (0.00) | 2504 (100.00) | 0 (0.00) | 525 (100.00) | 0 (0.00) | 1285 (100.00) | |||
| Fathers | 2114 (87.86) | 292 (12.14) | 470 (91.62) | 43 (8.38) | 1164 (95.02) | 61 (4.98) | |||
| Mothers | 2258 (90.61) | 234 (9.39) | 480 (91.78) | 43 (8.22) | 1218 (95.31) | 60 (4.69) | |||
| Siblings | 2415 (97.07) | 73 (2.93) | 541 (97.30) | 15 (2.70) | 1167 (93.96) | 75 (6.04) | |||
| Offspring | 694 (99.57) | 3 (0.43) | 212 (100.00) | 0 (0.00) | 307 (99.68) | 1 (0.32) | |||
| Total | 7481 (70.66) | 3106 (29.34) | 1703 (73.12) | 626 (26.88) | 3856 (72.24) | 1482 (27.76) | |||
| Control families | |||||||||
| Probands | 7372 (98.66) | 100 (1.34) | 1564 (99.62) | 6 (0.38) | 3817 (99.45) | 21 (0.55) | |||
| Fathers | 7112 (97.03) | 218 (2.97) | 1490 (96.75) | 50 (3.25) | 3736 (99.28) | 27 (0.72) | |||
| Mothers | 7344 (98.67) | 99 (1.33) | 1543 (98.66) | 21 (1.34) | 3794 (99.32) | 26 (0.68) | |||
| Siblings | 9952 (99.61) | 39 (0.39) | 2101 (99.72) | 6 (0.28) | 5161 (99.59) | 21 (0.41) | |||
| Offspring | 2093 (99.90) | 2 (0.10) | 632 (100.00) | 0 (0.00) | 1014 (99.80) | 2 (0.20) | |||
| Total |
33873 (98.67) | 458 (1.33) | 7330 (98.88) | 83 (1.12) | 17522 (99.45) | 97 (0.55) | |||
| OR | 95% CI | V1 | OR | 95% CI | V1 | OR | 95% CI | V1 | |
| Cases vs. controls | |||||||||
| Fathers | 4.51** | 3.75–5.42 | 0.18 | 2.73** | 1.79–4.16 | 0.11 | 7.25** | 4.57–11.51 | 0.14 |
| Mothers | 7.69** | 6.02–9.82 | 0.19 | 6.58** | 3.84–11.30 | 0.17 | 7.19** | 4.50–11.49 | 0.14 |
| Siblings | 7.72** | 5.21–11.44 | 0.11 | 9.72** | 3.73–25.32 | 0.11 | 15.78** | 9.61–25.93 | 0.18 |
| Offspring | 4.52 | 0.75–27.15 | 0.03 | - | - | - | 1.65 | 0.15–18.28 | 0.01 |
| Total | 5.96** | 5.20–6.82 | 0.16 | 4.44** | 3.28–6.02 | 0.12 | 9.21** | 7.03–12.06 | 0.15 |
1 Cramer's V
* = p<0.05
** = p<0.001