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. 2017 May 17;12(5):e0177752. doi: 10.1371/journal.pone.0177752

Table 5. Associations between selected subject characteristics and discordant QuantiFERON®-TB Gold In-Tube test and tuberculin skin test results using either a 15 mm or 10 mm cutoff.

TST ≥ 15 mm but negative QFT-GIT TST ≥ 10 mm but negative QFT-GIT TST <15 mm but positive QFT-GIT a
Characteristic n Concord n Discord aOR (95% CI) n Concord n Discord aOR (95% CI) n Concord n Discord OR (95% CI)
Age b 760 18 1.2 (1.0–1.3) 741 37 1.1 (1.0–1.2) 760 9 Not retained
TB prevalence in birth country
 <20 cases per 100,000 700 5 1.0 690 15 1.0 700 8 Not retained
 20–100 cases per 100,000 19 3 18.0 (3.9–83.8) 17 5 13.5 (4.2–43.6) 19 1
 >100 cases per 100,000 41 10 27.8 (8.8–88.0) 34 17 24.2 (10.4–56.4) 41 0
Reactivity to M. avium PPD
 No 702 15 Not retained 689 28 1.0 702 8 Not retained
 Yes 58 3 52 9 6.2 (2.4–16.1) 58 1

TST = tuberculin skin test; QFT-GIT = QuantiFERON®-TB Gold In-Tube test; n Concord = the number of subjects with concordant TST (at indicated cutoff) and QFT-GIT results; n Discord = the number of subjects with discordant TST (at indicated cutoff) and QFT-GIT results; aOR (95% CI) = adjusted Odds Ratios (95% confidence intervals) with boldface font indicating statistically significant differences; TB = tuberculosis.

a TST induration was 0 mm for all subjects with TST <15 mm but positive QFT-GIT results so that all had TST-negative but QFT-GIT-positive discordance regardless of the TST cutoff used;

b Increase in odds for each year of age.