Table 5. Associations between selected subject characteristics and discordant QuantiFERON®-TB Gold In-Tube test and tuberculin skin test results using either a 15 mm or 10 mm cutoff.
TST ≥ 15 mm but negative QFT-GIT | TST ≥ 10 mm but negative QFT-GIT | TST <15 mm but positive QFT-GIT a | |||||||
---|---|---|---|---|---|---|---|---|---|
Characteristic | n Concord | n Discord | aOR (95% CI) | n Concord | n Discord | aOR (95% CI) | n Concord | n Discord | OR (95% CI) |
Age b | 760 | 18 | 1.2 (1.0–1.3) | 741 | 37 | 1.1 (1.0–1.2) | 760 | 9 | Not retained |
TB prevalence in birth country | |||||||||
<20 cases per 100,000 | 700 | 5 | 1.0 | 690 | 15 | 1.0 | 700 | 8 | Not retained |
20–100 cases per 100,000 | 19 | 3 | 18.0 (3.9–83.8) | 17 | 5 | 13.5 (4.2–43.6) | 19 | 1 | |
>100 cases per 100,000 | 41 | 10 | 27.8 (8.8–88.0) | 34 | 17 | 24.2 (10.4–56.4) | 41 | 0 | |
Reactivity to M. avium PPD | |||||||||
No | 702 | 15 | Not retained | 689 | 28 | 1.0 | 702 | 8 | Not retained |
Yes | 58 | 3 | 52 | 9 | 6.2 (2.4–16.1) | 58 | 1 |
TST = tuberculin skin test; QFT-GIT = QuantiFERON®-TB Gold In-Tube test; n Concord = the number of subjects with concordant TST (at indicated cutoff) and QFT-GIT results; n Discord = the number of subjects with discordant TST (at indicated cutoff) and QFT-GIT results; aOR (95% CI) = adjusted Odds Ratios (95% confidence intervals) with boldface font indicating statistically significant differences; TB = tuberculosis.
a TST induration was 0 mm for all subjects with TST <15 mm but positive QFT-GIT results so that all had TST-negative but QFT-GIT-positive discordance regardless of the TST cutoff used;
b Increase in odds for each year of age.