Table 4. CD4 counts and HIV-RNA levels at EOT and 12 weeks after EOT from fitting an analysis of covariance model controlling for baseline values, according to use of ribavirin (RBV).
HIV lab markers |
RBV in DAA | RBV-free DAA | RBV in DAA | RBV-free DAA | ||
---|---|---|---|---|---|---|
Unadjusted Mean (95% CI) | p-value | Adjusted Mean (95% CI) | p-value | |||
CD4 count at EOT | ||||||
cells/mm3 | 481 (454, 507) | 616 (588, 644) | < .001 | 480 (453, 507) | 616 (588, 644) | < .001 |
CD4 count 12 weeks after EOT | ||||||
cells/mm3 | 623 (589, 656) | 663 (628, 699) | 0.1 | 624 (590, 657) | 665 (629, 700) | 0.1 |
HIV-RNA at EOT | ||||||
log10 copies/mL | 0.5 (0.4, 0.6) | 0.7 (0.5, 0.8) | 0.07 | 0.5 (0.4, 0.6) | 0.7 (0.6, 0.8) | 0.03 |
HIV-RNA 12 weeks after EOT | ||||||
log10 copies/mL | 0.6 (0.4, 0.7) | 0.6 (0.5, 0.8) | 0.4 | 1.0 (0.4, 0.7) | 0.6 (0.5, 0.8) | 0.4 |
Adjusted mean: adjusted for gender, age, HCV genotype, decompensate cirrhosis and diabetes.
HIV-RNA also adjusted for CD4 count at DAA initiation and vice versa.