Skip to main content
. 2017 May 17;12(5):e0177402. doi: 10.1371/journal.pone.0177402

Table 4. CD4 counts and HIV-RNA levels at EOT and 12 weeks after EOT from fitting an analysis of covariance model controlling for baseline values, according to use of ribavirin (RBV).


HIV lab markers
RBV in DAA RBV-free DAA   RBV in DAA RBV-free DAA  
  Unadjusted Mean (95% CI) p-value Adjusted Mean (95% CI) p-value
CD4 count at EOT
    cells/mm3 481 (454, 507) 616 (588, 644) < .001 480 (453, 507) 616 (588, 644) < .001
CD4 count 12 weeks after EOT
    cells/mm3 623 (589, 656) 663 (628, 699) 0.1 624 (590, 657) 665 (629, 700) 0.1
HIV-RNA at EOT
    log10 copies/mL 0.5 (0.4, 0.6) 0.7 (0.5, 0.8) 0.07 0.5 (0.4, 0.6) 0.7 (0.6, 0.8) 0.03
HIV-RNA 12 weeks after EOT
    log10 copies/mL 0.6 (0.4, 0.7) 0.6 (0.5, 0.8) 0.4 1.0 (0.4, 0.7) 0.6 (0.5, 0.8) 0.4

Adjusted mean: adjusted for gender, age, HCV genotype, decompensate cirrhosis and diabetes.

HIV-RNA also adjusted for CD4 count at DAA initiation and vice versa.