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A) Crystal structures of RebH24 and BM325, and a homology model of POP26 containing a covalently-linked dirhodium cofactor27. Cofactors shown as red sticks. Targeted residues shown as blue and green spheres; green indicates mutations in optimized variants. B) Codon changes per gene for each library. C) Reactions catalyzed by CCM library members (Ar=4-methoxyphenyl).
