Figure 3.

Brain functional connections that contribute most to the prediction of 3-month improvement in pain. A. Functional connections with most positive weight in the SVM (improvers > non-improvers). A1. We initially examined 100 connections as there appeared to be diminishing change in weight with the addition of new connections beyond these. A2. These 100 connections, when visualized on the brain, appeared to be concentrated in the frontal and parietal cortices on the left side of the brain (each sphere represents a region making one of these 100 connections, and the size of the sphere codes the number of these 100 connections made by that region). Regions are colored according to their associated lobe in the connectogram in A4. A3. Compared to templates of 10 common resting state networks based on independent components analysis (3 visual networks, default mode network, cerebellar network, sensorimotor network, salience network, frontal network, right frontoparietal network, left frontoparietal network) [39], the left frontoparietal network (L-FPN) appeared to contain pairs of locations with the greatest percentage of the altered connections. A4. Diagram of connections (connectogram) showing the 100 connections in A1 (see supplemental information for region abbreviations). B. Identical figures for connections with most negative weight in the SVM (non-improvers > improvers). Notice that these regions do not tend to align preferentially with any common resting state networks.