Table II.

Changes in pain frequency, intensity and analgesic use after 3 months of simvastatin treatment in total study group and by concomitant hydroxycarbamide use

	Total group				On HC (n=10)				Not on HC (n=9)
	Baseline	Simvastatin	% change	p-value	Baseline	Simvastatin	% change	p-value	Baseline	Simvastatin	% change	p-value
Pain rate	0.20 (0.06, 0.27)	0.03 (0.02, 0.15)	−85	0.0003	0.15 (0.04, 0.32)	0.03	−80	0.006	0.25 (0.16, 0.41)	0.047	−81	0.013
Analgesic use	0.09 (0, 0.22)	0.03 (0, 0.09)	−67	0.003	0.08 (0, 0.2)	0.03 (0, 0.09)	−63	0.04	0.09 (0.03,0.23)	0.03 (0.01,0.09)	−67	0.04
Pain intensity	3.0 (1.7, 5.0)	2.3 (1.1, 5.6)	−23	0.2762	2.7 (1.5, 5.2)	2.2 (1.3,4.5)	−19	0.43	3.0 (2.0,5.9)	3.0 (0.5,6.3)	0	0.57

Values are expressed as median and 25–75% interquartile range

Analgesic medications included oral or parenteral opioids and non-steroidal anti-inflammatory drugs.

HC, hydroxycarbamide