Table IV.
Comparison of changes in soluble (s) biomarker levels after simvastatin by hydroxycarbamide use.
| Biomarker | HC (n=10*) | No HC (9*) | ||||||
|---|---|---|---|---|---|---|---|---|
| baseline | simvastatin | %change | p-value | baseline | simvastatin | %change | p-value | |
| NOx (μM) | 21.4 | 28 | +31 | 0.39 | 30 | 28.2 | −6 | 0.82 |
| hs-CRP (mg/l) | 1.8 (1.2,9.9) | 1.05 (.58,1.7) | −42 | 0.008 | 3 | 2.2 | −27 | 0.15 |
| sE-selectin (ng/ml) | 232.4 | 177.6 | −24 | 0.03 | 370.3 | 355.3 | −4 | 0.44 |
| sP-selectin (ng/ml) | 405.8 | 352.2 | −13 | .94 | 487.3 | 586 | 20 | 0.25 |
| sVEGF (ng/ml) | 148.9 | 96.0 | −36 | .03 | 98.6 | 116.9 | 19 | 0.13 |
| sICAM-1 (ng/ml) | 462.9 | 377.4 | −86 | .008 | 537.6 | 573.3 | 7 | 0.56 |
| sICAM-3 (ng/ml) | 160.4 | 128.8 | −20 | .008 | 151.8 | 124.2 | −18 | 0.85 |
| sVCAM-1 (ng/ml) | 822.1 | 749.6 | −9 | 0.58 | 1110 | 1129 | 2 | 0.20 |
*
Analyses of sE-selectin, sP-selectin, ICAM-1, ICAM-3 and VCAM-1 was limited to 14 subjects (8 on HC, 6 not on HC)
HC, hydroxycarbamide; hs-CRP, high sensitivity C-reactive protein; NOx, nitrite/nitrate; sE-selectin, soluble E-selectinsICAM-1, -3, soluble intercellular adhesion molecule 1, 3; sP-selectin, soluble P-selectin; sVCAM-1, vascular cell adhesion molecule 1; sVEGF, soluble vascular endothelial growth factor.