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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2017 Apr 13;174(4):399–412. doi: 10.1002/ajmg.b.32529

Table 3.

Generalized Estimating Equation Analysis of Phenotypes by Parenting Stress Group and CGG Repeats: Testing joint null hypotheses that both interaction terms are not different from zero.

BMI
(kg/m2)
# health
symptoms
Limitations in
physical
activities
Limitations in
climbing several
flights of stairs

Parental age −.07 (.02)** .00 (.01) .02 (.00)*** .02 (.00)***
Education (in years) −.23 (.03)*** −.10 (.02)*** −.03 (.00)*** −.04 (.00)***
Gender (female=1) −1.04 (.17)*** .20 (.11)+ .01 (.02) .10 (.02)***
Parenting stress group
(comparison group=0)
.43 (.27) .77 (.17)*** .05 (.03) .09 (.03)**
CGG repeats- linear .01 (.01) .01 (.01) .00 (.00) .002 (.002)
CGG repeats- squared −.002 (.001)* −.002 (.001)* −.00 (.00) −.00 (.00)
CGG repeats- linear X
parenting stress group
−.02 (.04) −.05 (.03) −.011 (.005)* −.011 (.005)*
CGG repeats- squared X
parenting stress group
.007 (.003)* .005 (.002)** .0006 (.0003)* .0008 (.0004)*

Test: both interactions are
zero (2df joint test)
Chi-sq=7.52*
P=0.023
Chi-sq=7.73*
P=0.021
Chi-sq=6.18*
P=0.045
Chi-sq=6.67*
P=0.036

limitations in
cognitive
functioning
depression anxiety age (yrs) at
menopause

Parental age .02 (.00)*** −.06 (.031) −.10 (.03)** −.03 (.03)
Education (in years) −.06 (.01)*** −.28 (.04)*** −.18 (.04)*** .19 (.06)***
Gender (female=1) −.12 (.03)*** .86 (.21)*** 1.09 (.22)*** --
Parenting stress group
(comparison group=0)
.08 (.05) 0.84 (.36)* 1.02 (.37)** −.45 (.41)
CGG repeats- linear −.00 (.00) −.01 (.02) −.01 (.02) .02 (.02)
CGG repeats- squared −.00 (.00) −.00 (.00) −.00 (.00) −.004 (.002)*
CGG repeats- linear X
parenting stress group
−.01 (.01) - - -
CGG repeats- squared X
parenting stress group
.0012 (.0006)* - - -

Test: both interactions are
zero (2df joint test)
Chi-sq=4.76+
P=0.093
Chi-sq=3.28
P=0.194
Chi-sq=2.48
P=.290
Chi-sq=1.71
P=.426
a

CGG repeat length was Winsorized at 60, and centered at 30.

*

p < .05

**

p < .01

***

p < .001