Subject area	Biology
More specific subject area	Human Immunology
Type of data	Tables (x3) and Figures (x12)
How data was acquired	Flow cytometry (Fortessa; BD biosciences); Gene expression profiling (NanoString Technologies)
Data format	Analyzed flow cytometry files and normalized gene expression counts (from Nanostring)
Experimental factors	Flow cytometry and gene expression profiling was performed in freshly isolated PBMCs or CD4+ T cells. Cytokine production was assessed following in vitro stimulation with PMA + ionomycin. Cell proliferation was assessed by flow cytometry by culturing cells in vitro with anti-CD3/anti-CD28 stimulation.
Experimental features	Delineation of the Treg compartment was performed in human peripheral blood cells using polychromatic flow cytometry. The global transcriptional profile of the assessed T cell subsets was assessed in sorted cells isolated ex vivo.
Data source location	Samples from human volunteers and T1D patients were collected in Cambridge, UK.
Data accessibility	All primary non-clinical data are available in this article. The DILT1D data from individuals prior to normalization as a group are available, however they cannot be anonymized sufficiently to be able to put into the public domain without risk of participant identification. Data are available on request, through the Cambridge University institutional repository (DOI link:https://doi.org/10.17863/CAM.832).
Related research article	The data presented in this paper support the research article “Human IL-6RhiTIGIT−CD4+CD127lowCD25+T cells display potent in vitro suppressive capacity and a distinct Th17 profile” (Ferreira RC et al., 2017)[1].