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. 2017 May 17;7:2023. doi: 10.1038/s41598-017-02205-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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T₂ and T₃ reduce hepatic lipid accumulation in HFD fed rats associated with increased acylcarnitine flux. (A) Representative graph showing Triglycerides (TGs) content in rats liver treated respectively with NCD, HFD, HFD+T₂, HFD+T₃ for 1 week. Values are means ± SEM (n = 4). *P < 0.05 in NCD Vs HFD; ^#P < 0.05 in HFD Vs HFD+T₂/HFD+T₃. Metabolomics profiles of (B) short chain acylcarnitines (SCAC), (C) medium chain acylcarnitines (MCAC), (D) long chain acylcarnitines (LCAC) and (E) very long chain acylcarnitines (VLCAC) in NCD, HFD, HFD+T₂ and HFD+T₃ treated rats. Values are means ± SEM (n = 4). *P < 0.05 in NCD Vs HFD; ^#P < 0.05 in HFD Vs HFD+T₂/HFD+T₃.