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. 2017 May 17;7:2017. doi: 10.1038/s41598-017-01666-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Corticosterone exposure (Cort-black bars) had no effect on (A) glucocorticoid receptor alpha (GRα) protein in whole placentae of male C57/BL6 mouse fetuses at E14.5 compared with untreated controls (Untr-white bars) nor was it different between sexes; (B) GRα protein in whole placentae of untreated male (white bars) and female (black bars) C57/BL6 mouse fetuses at E14.5. Male and female E14.5 placental tissue (n = 6 pooled for each sex and treatment) were immunoprecipitated to isolate OGT and immunoprobed with a GRα antibody (C). This demonstrated an approximate 70% increase in the level of OGT associated glucocorticoid receptor in response to Cort exposure in male fetuses with no apparent difference in the level of OGT immunoprecipitated GRα in female placentae between treatment groups. The level GRα that immunoprecipitated with OGT was approximately 30% greater in placentae of control females than in males.