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. 2017 May 17;7:2018. doi: 10.1038/s41598-017-02291-1

Table 1.

Transcription factor binding sites in 5′-LTR PQS.

Group Lentivirus Transcription factor binding sites in LTR PQS Ref
Primate HIV-1 M GGGACTTTCCGCTGGGGACTTTCCAGGGAGGCGTGGCCTGGGCGGGACTGGGGAGTGG 49
SIVcpz GGGACTTTCCAAGGGACGTTCCAAGGGGGTGGGTCAGGGCGGAACAGGGCGTGG
HIV-2 GGGACTTTCCAGAAGGGGCTGTAACCAAGGGAGGGACATGGGAGGAGCTGGTGGGG 49
SIVmac GGGACTTTCCACAAGGGGATGTTACGGGGAGGTACTGGGGAGGAGCCGGTCGGG 50
SIVsm GGGACTTTCCACAAGGGGCTGTCATGGGGAGGTACTGGGGAGGAGCTGGCTGG
SIVstm GGGACTTTCCACAAGGGGCTGTAACAGGGGAGGTACTGGGAGGAACTGGTGGGG
HIV-1 N GGGACTTTACACATGGGGACTTTCCGCCGGGGACTTTCCAGGG
HIV-1 O GGGACTTTCCAGTGGGAGGGACAGGGGGCGGTTCGGGGAGTGG
SIVgor GGGACTTTCCGTGGAGGAAAGTCCCCGGGGGCGGAACTGGGAGGAGCAGGGGAGTGG
SIVcol GGGACTTTCCGTTCGGGACTTTCCAAGTTGGGAGGGACCTGGGCGGAGGGAAGGG
SIVmne GGGACTTTCCATAAGGGGATGTCATGGGGGGGTACTGGGGAGGAGCTGGTCGGG
SIVver GGGACTTTCCAGCACGGGACTTTCC AAGGCGGGACATGGGCGGTACGGGGAGTGG
SIVwcm GGGACTTCTAGCGGGACTTTCC AGGCGGTCATGGCGGTACGGGAGTGG
SIVrcm GGGACTTTCCACTGGCGCCTGCGCGCTGGTGTAAGGGACTTTCCAGACTGACGTGGGAGGGGGGTGTGG
SIVgrv GCGGTTGGGACTTTCCGCCAGGGACTTTCCACAGTGGGTGGATCGGAGGCGGTACAGGGGCGGTACTGGGAGTGG
SIVtal GGGACTTTCCACGTTGCTAAGGCAACGGGGGACGGACTGGGGCGGGGAGCGGGAGGAGTTGGGAGTGG
SIVlhoest GGGACTTTCCAGGACGGGCGGGGGAGG
SIVmnd-1 GGGACTTTCCAAACAGGGAGGGGGAGG
SIVsun GGGACTTTCCGGACAGGGAGGGGGAGG
SIVpat GGGACTTCCCAGGGTGGAGACTGGGCGGTACTGGGAGTGG 51
SIVagm sab1 GGGACTTTCC AGGGTGGAGACTGGGCGGTACTGGGAGTGG
SIVagm tan1 GGGACTTTCC AGGGTGGTGCGAGGGCGGTACTTGGGAGTGG
SIVmus1 GGGACTTTCCAGTCACCATGACTACGGGGCCCGGTTGCTGAGGCAATCGGGGCGGACTCGTGGGTGGGACTGGGCGGTACTGGGAGTGG
SIVmus3 GGGACTTTCCAGTTACCATGACTACGGGGCTGGTTGCTGAGGCAACCAGGGCGGACTCGTGGGTGGGACTGGGAGGAACGGGGAGTGG
SIVdeb GGGGAGGGCCTGGGTGGTACGGGGAGTGG
SIVsyk GGCCCAGGGGAGGAGCCTGGGCGGGGGAAGG
SIVwrc GGGACATTGGGAGGAGACTGGGAGGTGCCTTGTGG
SIVden GGGCGGACTCAGGGGAGGGCCTGGGAGGTCTCTGGG
SIVgsn GGGCGGACTCGTGGGTGGGACTGGGAGGCCGGGAGTGG
SIVdrl GTGGCAGGGACTTTCCAGGGTGACGTGGGTTGGGGGAGTGG
SIVmon GGGGCCCGGTTGCTGCGGCAACCGGGCGGTCCAAAGGACTTGGTGGGTGGACCCGGGGAGTGG
SIVmus2 GGGGCCCGGTTGCCGCAGCAACCGGGGCGGACTCAGGGCGGACTGGGAGGGACCTGAGAGTGG
Bovine JDV GGGGAGAAAGGGAACAGGTGGGGACGACCGGG(ACCTTTCC)

Binding sites for NFκB are in bold. Sp1 binding sites reported in the literature are indicated in italics and are underlined. Sp1 binding sites predicted by Physbinder are underlined.