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. 2017 May 17;7:1999. doi: 10.1038/s41598-017-01767-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Blood transcriptome of patients with dual TB and DM burden compared to TB or DM alone. (A) Differentially expressed genes between patients with distinct clinical phenotypes (class). The comparison between two classes is indicated at the top of each bar. Red and blue bars represent the number of DEGs which are up- or down-regulated, respectively in the first class of the comparison. The purple bar shows the number of DEGs in the comparison TBDM vs. DM (“TBDM total”). The number of DEGs which are in common to two comparisons are shown inside green areas connecting two horizontal bars (“TB shared”). Genes which are uniquely differentially expressed in TBDM vs. DM is shown by the brown bar (“TBDM unique”). (B) Top transcriptional regulators in “TB shared” DEGs. Ingenuity’s Upstream Regulator Analysis was performed using “TB shared” (green bars), “TBDM unique” (brown bars), and “TBDM total” DEGs (purple bars). The x-axis indicates the significance of the enrichment for the upstream regulators on the left. (C) Top transcriptional regulators in “TBDM unique” DEGs identified by the same approach as in (B).