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. 2017 May 17;7:1999. doi: 10.1038/s41598-017-01767-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased activity of pathways associated with epigenetic regulation in diabetic TB patients. (A) Single sample Gene Set Enrichment Analysis (ssGSEA) was performed for each patient using the genes ranked by their MDP score and Reactome pathways as gene sets (P < 0.01, 1,000 permutations). Colors represent increase (red) or decrease (blue) in pathway expression activity vs. healthy controls as given by the normalized enrichment score (NES). Bars at the bottom indicate patients which are perturbed (darker color) or not-perturbed (light color). (B) Mean NES (values inside the circles) of the patients and pathways for each functional group. The size of the circles is proportional to the mean NES and color indicates positive (red) or negative (blue). (C) Pathways associated with “DNA methylation”. Spearman correlation between the expression activity of “DNA methylation” pathway and all other Reactome pathways across all patients. The network shows the pathways with correlation >0.6 (red circles) or <−0.6 (blue circles). The thickness of the edges is proportional to the number of genes in common between two given pathways (nodes).