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. 2017 May 17;7:2029. doi: 10.1038/s41598-017-01905-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Estrogen signaling regulates EVs miRNA cargo of primary synovial fibroblast cells. Estrogen inhibitor (Letrozole) down-regulates (a) miR-26a-5p, (b) miR-146a-5p, (c) miR-328-5p, (d) miR-4654 and up-regulated (e) miR-7107-5p in EVs cargo of human synovial fibroblast cells. Data (means ± SD, n = 4–6,) are represented as the fold change in expression compared with control (*p < 0.05, **p < 0.01).