Table 2.
pEC50 values of S1P derivatives at S1P receptors.
| C16 | C17 | S1P | C19 | C20 | |
|---|---|---|---|---|---|
| S1P1 (n = 4) | 6.5 ± 0.3 | 6.9 ± 0.2 | 7.1 ± 0.3 | 6.6 ± 0.2 | n.r. |
| S1P2 1 (n = 4) | 6.9 ± 0.1 | 7.0 ± 0.1 | 7.5 ± 0.0 | 6.7 ± 0.1 | 6.3 ± 0.1 |
| S1P2 2 (n = 3) | 6.5 ± 0.2 | 7.1 ± 0.1 | 7.3 ± 0.2 | 6.5 ± 0.2 | 6.0 ± 0.2 |
| S1P4 (n = 4) | 7.3 ± 0.2 | 7.1 ± 0.1 | 7.0 ± 0.1 | 6.1 ± 0.1 | 5.6 ± 0.1 |
| S1P5 (n = 2) | 7.4 ± 0.2 | 6.9 ± 0.1 | 7.3 ± 0.5 | 6.7 ± 0.1 | n.r. |
The experimental EC50 for all S1P derivatives were determined from the dose-response curves of the aequorin-based functional assays. Mean values of pEC50 (negative logarithm of EC50) on 2 to 4 independent experiments are presented along with the corresponding S.E.M. values.
1S1P5 cells, 2CHO-Aeq cells, n.r. = not reliable.