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. 2017 May 18;8:533. doi: 10.3389/fimmu.2017.00533

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Copyright © 2017 Zhang, Oberoi, Oelsner, Waldmann, Lindner, Tonn and Wels.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activity of NK-92/5.28.z against ErbB2-expressing breast carcinoma cells. Cytotoxicity of CAR-engineered ErbB2-specific NK-92/5.28.z cells (filled circles) against ErbB2-overexpressing and trastuzumab-sensitive MDA-MB453 (left), or ErbB2-overexpressing and trastuzumab-resistant JIMT-1 (middle) and CAL-51 (right) breast carcinoma cells was investigated in flow cytometry-based cytotoxicity assays after coincubation of NK cells and tumor cells at different effector to target ratios (E/T) for 2 h. Parental NK-92 cells were included for comparison (open circles). Mean values ± SEM are shown; n = 3.