Table 1.
Target | Antibody | Hinge | TM | Signaling | Gene transfer | Cancer type | In vivo model | Treatment | Reference | ||
---|---|---|---|---|---|---|---|---|---|---|---|
ErbB2 (HER2) | FRP5 | mCD8α | mCD3ζ | mCD3ζ | Retrovirus | Breast ca. Ovarian ca. SCC |
CD-1 nude | Local co-injection | Uherek et al. (23) | ||
ErbB2 (HER2) | FRP5 | mCD8α | mCD3ζ | mCD3ζ | Retrovirus | Breast ca. | BALB/c nude | Systemic | Daldrup-Link et al. (63), Meier et al. (64) | ||
ErbB2 (HER2) | FRP5 | mCD8α | mCD3ζ | mCD3ζ | Retrovirus | Brain metastasis | Athymic nude rats | Systemic (with FUS) | Alkins et al. (65), Alkins et al. (66) | ||
ErbB2 (HER2) | 4D5-8 | hIgG2 | hFcεRIγ | hFcεRIγ | Retrovirus | Breast ca. | NSG | Systemic | Clemenceau et al. (58) | ||
ErbB2 (HER2) | FRP5 | hCD8α | hCD3ζ hCD28 hCD137 |
hCD3ζ hCD28-CD3ζ hCD137-CD3ζ |
Lentivirus | Breast ca. Ovarian ca. Melanoma RCC |
NSG | Systemic | Schönfeld et al. (67) | ||
ErbB2 (HER2) | n.s. | hCD8α | hCD28 | hCD28-CD3ζ | Electroporation | Breast ca. | BALB/c nude | Systemic | Liu et al. (68) | ||
ErbB2 (HER2) | FRP5 | hCD8α | hCD28 | hCD28-CD3ζ | Lentivirus | GBM | NSG C57BL/6 |
Local | Zhang et al. (69) | ||
Epidermal growth factor receptor (EGFR) | 528 | n.s. | n.s. | hCD28-CD3ζ | Lentivirus | Brain metastasis | NSG | Local (combined with HSV-1) | Chen et al. (70) | ||
EGFR | R-1 | hCD8α | hCD28 | hCD28-CD3ζ | Lentivirus | GBM | NSG | Local | Genßler et al. (71) | ||
EGFR/EGFRvIII | 528 | n.s. | hCD28 | hCD28-CD3ζ | Lentivirus | GBM | NSG | Local | Han et al. (72) | ||
EGFR/EGFRvIII | 225 | hCD8α | hCD28 | hCD28-CD3ζ | Lentivirus | GBM | NSG | Local | Genßler et al. (71) | ||
EGFRvIII | MR1-1 | hCD8α | hCD28 | hCD28-CD3ζ | Lentivirus | GBM | NSG | Local | Genßler et al. (71) | ||
GD2 | ch14.18 | mCD8α | mCD3ζ | mCD3ζ | Retrovirus | NB Breast ca. Melanoma |
NSG | Local | Esser et al. (56), Seidel et al. (59) | ||
Epithelial cell adhesion molecule (EpCAM) | MOC31 | mCD8α | mCD3ζ | mCD3ζ | Retrovirus | Prostate ca. | Athymic nude rats | Systemic | Tavri et al. (55), Meier et al. (73) | ||
EpCAM | MOC31 | hCD8α | hCD28 | hCD28-CD3ζ | Lentivirus | Breast ca. | – | – | Sahm et al. (28) | ||
CD19 | FMC63 | mCD8α | mCD3ζ | mCD3ζ | Retrovirus | B-ALL | – | – | Romanski et al. (48), Romanski et al. (53) | ||
CD19 | FMC63 | mCD8α | mCD3ζ | mCD3ζ | mRNA transfection | B-ALL CLL |
– | – | Boissel et al. (50) | ||
CD19 | FMC63 | mCD8α | mCD3ζ | mCD3ζ | mRNA transfection Lentivirus |
B-ALL | CLL | Burkitt’s lymphoma | – | – | Boissel et al. (51) |
CD19 | FMC63 | mCD8α | mCD3ζ | mCD3ζ | Lentivirus | B-ALL CLL |
NOD/SCID NSG |
Local Systemic |
Boissel et al. (52) | ||
CD19 | FMC63 | hCD8α | hCD3ζ hCD28 hCD137 |
hCD3ζ hCD28-CD3ζ hCD137-CD3ζ |
Lentivirus | B-ALL Burkitt’s lymphoma |
NSG | Systemic | Oelsner et al. (74) | ||
CD20 | Leu-16 | mCD8α | mCD3ζ | mCD3ζ | Retrovirus | B-ALL CLL Burkitt’s lymphoma |
NSG | Local co-injection | Müller et al. (49) | ||
CD20 | Leu-16 | mCD8α | mCD3ζ | mCD3ζ | mRNA transfection | B-ALL | CLL | Burkitt’s lymphoma | – | – | Boissel et al. (51) |
Lentivirus | |||||||||||
CD20 | Leu-16 | mCD8α | mCD3ζ | mCD3ζ | Lentivirus | B-ALL | NOD/SCID | Local | Boissel et al. (52) | ||
CLL | NSG | Systemic | |||||||||
CD3 | n.s. | hCD8α | hCD8α | hCD28-CD137-CD3ζ | Lentivirus | PTCL | NSG | Systemic | Chen et al. (75) | ||
T-ALL | |||||||||||
CD5 | n.s. | hCD8α | hCD8α | hCD28-CD137-CD3ζ | Lentivirus | PTCL T-ALL CLL Burkitt’s lymphomaSézary syndrome |
NSG | Systemic | Chen et al. (76) | ||
CD138 | 4B3 | hCD8α | hCD3ζ | hCD3ζ | Lentivirus | MM | NOD/SCID | Systemic | Jiang et al. (54) | ||
CS1 | Luc90 | n.s. | n.s. | hCD28-CD3ζ | Lentivirus | MM | NSG | Systemic | Chu et al. (77) | ||
EBNA3C peptide | EBNA Clone 315 | hCD8α | hCD8α | hCD137-CD3ζ | Retrovirus | BLCL | – | – | Tassev et al. (78) | ||
gp100209–217 peptide | GPA7 | n.s. | HLA-A2 | hCD3ζ | Electroporation | Melanoma | NOD/SCID | Systemic | Zhang et al. (57) | ||
WT1126 peptide | Q2L | hCD8α | hCD8α | hCD137-CD3ζ | Retrovirus | B-ALL AMoL NB |
– | – | Zhao et al. (79) |
TM, transmembrane domain; n.s., not specified; m, murine; h, human; SCC, squamous cell carcinoma; RCC, renal cell carcinoma; GBM, glioblastoma; NB, neuroblastoma; B-ALL, B-cell acute lymphoblastic leukemia; CLL, chronic lymphocytic leukemia; PTCL, peripheral T-cell lymphoma; T-ALL, T-cell acute lymphoblastic leukemia; MM, multiple myeloma; BLCL, Epstein–Barr virus (EBV)-transformed lymphoblastoid B cell line; AMoL, acute monocytic leukemia; FUS, MRI-guided focused ultrasound.